منابع مشابه
Myosin 7 and its adaptors link cadherins to actin
Cadherin linkages between adjacent stereocilia and microvilli are essential for mechanotransduction and maintaining their organization. They are anchored to actin through interaction of their cytoplasmic domains with related tripartite complexes consisting of a class VII myosin and adaptor proteins: Myo7a/SANS/Harmonin in stereocilia and Myo7b/ANKS4B/Harmonin in microvilli. Here, we determine h...
متن کاملCadherins.
CELL ADHESION: General Considerations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307 CADHERIN-MEDIATED MORPHOGENESIS ............................. 309 CADHERINS AND ADHERENS-TYPE JUNCTIONS . . . . . . . . . . . . . . . . . . . . . . . . 313 CADHERIN STRUCTURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 314 FUNCTIONAL SITES OF CADH...
متن کاملNoddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.
In hair cells of the inner ear, sound or head movement increases tension in fine filaments termed tip links, which in turn convey force to mechanosensitive ion channels to open them. Tip links are formed by a tetramer of two cadherin proteins: protocadherin 15 (PCDH15) and cadherin 23 (CDH23), which have 11 and 27 extracellular cadherin (EC) repeats, respectively. Mutations in either protein ca...
متن کاملNanomechanics of carbon nanotubes.
Some of the most important potential applications of carbon nanotubes are related to their mechanical properties. Stiff sp2 bonds result in a Young's modulus close to that of diamond, while the relatively weak van der Waals interaction between the graphitic shells acts as a form of lubrication. Previous characterization of the mechanical properties of nanotubes includes a rich variety of experi...
متن کاملNanomechanics of HaloTag tethers.
The active site of the Haloalkane Dehydrogenase (HaloTag) enzyme can be covalently attached to a chloroalkane ligand providing a mechanically strong tether, resistant to large pulling forces. Here we demonstrate the covalent tethering of protein L and I27 polyproteins between an atomic force microscopy (AFM) cantilever and a glass surface using HaloTag anchoring at one end and thiol chemistry a...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-49518-x